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KMID : 0545120050150020434
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Journal of Microbiology and Biotechnology
2005 Volume.15 No. 2 p.434 ~ p.437
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Isolation of Sangivamycin from Streptomyces sp. A6497 and its Herbicidal Activity
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Hwang EI
Yun BS/Choi SW/Kim JS/Lim SJ/Moon JS/Lee SH/Kim SU
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Abstract
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During the screening for the inhibitors of cellulose biosynthesis as herbicides we discovered a Streptomyces sp. A6497 with a selective antifungal activity against cellulose containing Phytophthora parasitica but not against cellulose lacking Candida albicans. The inhibitor was isolated and identified using a series of chromatographies. Based on structure analyses with UV spectrophotometry mass and various NMR the inhibitor was identified as sangivamycin. The compound exhibited strong antifungal activities against P. parasitica (MIC; 3.125 μg/ml). In particular it showed strong herbicidal activities against various weeds in the greenhouse experiment. Taken together these results suggest that sangivamycin is a useful lead compound for the development of new herbicides.
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